Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.397


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.741.0e-03Click!
HOXA6chr7_-_271538920.665.0e-03Click!
HOXB7chr17_-_44042924-0.214.4e-01Click!
HOXB6chr17_-_44037332-0.146.2e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_101488380 11.802 NM_001195045
 YAP1
Yes-associated protein 1
chr8_-_122722674 10.135 NM_005328
 HAS2
hyaluronan synthase 2
chr3_-_55489973 9.249 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_41709191 9.240 NM_002192
 INHBA
inhibin, beta A
chr21_-_34820916 7.486 NM_203418
 RCAN1
regulator of calcineurin 1
chr7_-_27149750 7.362 NM_019102
 HOXA5
homeobox A5
chr1_+_168898898 7.280 PRRX1
paired related homeobox 1
chr2_+_66516196 7.098 MEIS1
Meis homeobox 1
chr7_-_27171600 7.020 HOXA9
homeobox A9
chr7_-_27171648 6.376 HOXA9
homeobox A9
chr10_+_24795446 6.030 KIAA1217
KIAA1217
chr7_-_27171673 6.026 NM_152739
 HOXA9
homeobox A9
chr14_+_51025604 5.912 NM_001042481
 FRMD6
FERM domain containing 6
chr10_+_24795465 5.890 KIAA1217
KIAA1217
chr7_-_83662152 5.814 NM_006080
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_115960807 5.646 NM_001164344
NM_001164345
 ZBTB20

zinc finger and BTB domain containing 20

chr9_-_116920232 5.569 NM_002160
 TNC
tenascin C
chr2_-_164300758 5.469 NM_018086
 FIGN
fidgetin
chr7_-_27108826 5.354 NM_006735
 HOXA2
homeobox A2
chr9_+_117955890 5.272 NM_002581
 PAPPA
pregnancy-associated plasma protein A, pappalysin 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 139 entries
enrichment   p-value GO term description
3.35 2.34e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
3.20 4.93e-02 GO:0007435 salivary gland morphogenesis
3.01 3.62e-02 GO:0060688 regulation of morphogenesis of a branching structure
2.94 8.17e-03 GO:0051153 regulation of striated muscle cell differentiation
2.87 2.43e-02 GO:0048641 regulation of skeletal muscle tissue development
2.55 6.95e-04 GO:0007519 skeletal muscle tissue development
2.53 1.99e-05 GO:0048706 embryonic skeletal system development
2.47 1.02e-03 GO:0060538 skeletal muscle organ development
2.45 7.47e-03 GO:0048634 regulation of muscle organ development
2.45 7.47e-03 GO:0048704 embryonic skeletal system morphogenesis
2.44 1.23e-02 GO:0016202 regulation of striated muscle tissue development
2.43 3.34e-02 GO:0050808 synapse organization
2.34 3.11e-03 GO:0022612 gland morphogenesis
2.29 4.75e-07 GO:0007156 homophilic cell adhesion
2.27 3.16e-02 GO:0051147 regulation of muscle cell differentiation
2.05 1.56e-03 GO:0014706 striated muscle tissue development
2.04 1.53e-04 GO:0045165 cell fate commitment
2.04 6.12e-04 GO:0060537 muscle tissue development
2.00 3.52e-04 GO:0043062 extracellular structure organization
1.89 2.62e-02 GO:0048705 skeletal system morphogenesis

Gene overrepresentation in compartment category:

Showing 1 to 20 of 21 entries
enrichment   p-value GO term description
4.60 3.55e-02 GO:0005614 interstitial matrix
2.63 1.64e-02 GO:0005581 collagen
2.33 1.68e-02 GO:0031983 vesicle lumen
2.30 4.51e-02 GO:0034774 secretory granule lumen
2.09 1.20e-04 GO:0030016 myofibril
2.01 3.24e-04 GO:0043292 contractile fiber
1.96 2.91e-03 GO:0044420 extracellular matrix part
1.96 2.91e-03 GO:0044449 contractile fiber part
1.88 4.52e-02 GO:0030017 sarcomere
1.83 3.12e-08 GO:0005578 proteinaceous extracellular matrix
1.73 9.87e-08 GO:0031012 extracellular matrix
1.69 2.43e-02 GO:0070161 anchoring junction
1.50 2.48e-03 GO:0045202 synapse
1.47 6.48e-05 GO:0030054 cell junction
1.47 1.34e-02 GO:0009986 cell surface
1.44 1.83e-08 GO:0044421 extracellular region part
1.39 1.59e-04 GO:0005615 extracellular space
1.29 1.29e-07 GO:0005576 extracellular region
1.22 1.79e-04 GO:0044459 plasma membrane part
1.21 3.21e-09 GO:0005886 plasma membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
2.37 2.00e-02 GO:0003707 steroid hormone receptor activity
2.34 1.79e-02 GO:0004879 ligand-dependent nuclear receptor activity
1.80 2.56e-04 GO:0000975 regulatory region DNA binding
1.80 2.56e-04 GO:0001067 regulatory region nucleic acid binding
1.80 2.56e-04 GO:0044212 transcription regulatory region DNA binding
1.79 5.47e-04 GO:0010843 promoter binding
1.75 1.34e-02 GO:0008083 growth factor activity
1.74 3.41e-02 GO:0005539 glycosaminoglycan binding
1.71 3.52e-02 GO:0001871 pattern binding
1.71 3.52e-02 GO:0030247 polysaccharide binding
1.57 1.47e-08 GO:0043565 sequence-specific DNA binding
1.55 5.02e-03 GO:0003779 actin binding
1.51 1.80e-06 GO:0005509 calcium ion binding
1.42 9.27e-07 GO:0001071 nucleic acid binding transcription factor activity
1.42 9.27e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.39 6.33e-06 GO:0030528 transcription regulator activity
1.38 2.02e-05 GO:0005102 receptor binding
1.18 4.81e-02 GO:0004871 signal transducer activity
1.18 4.81e-02 GO:0060089 molecular transducer activity
1.09 6.85e-03 GO:0005515 protein binding