Motif ID: HOX{A6,A7,B6,B7}.p2

Z-value: 3.397


Transcription factors associated with HOX{A6,A7,B6,B7}.p2:

Gene SymbolEntrez IDGene Name
HOXA6 3203 homeobox A6
HOXA7 3204 homeobox A7
HOXB6 3216 homeobox B6
HOXB7 3217 homeobox B7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HOXA7chr7_-_271626880.741.0e-03Click!
HOXA6chr7_-_271538920.665.0e-03Click!
HOXB7chr17_-_44042924-0.214.4e-01Click!
HOXB6chr17_-_44037332-0.146.2e-01Click!


Activity profile for motif HOX{A6,A7,B6,B7}.p2.

activity profile for motif HOX{A6,A7,B6,B7}.p2


Sorted Z-values histogram for motif HOX{A6,A7,B6,B7}.p2

Sorted Z-values for motif HOX{A6,A7,B6,B7}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A6,A7,B6,B7}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_101488380 11.802 NM_001195045
YAP1
Yes-associated protein 1
chr8_-_122722674 10.135 NM_005328
HAS2
hyaluronan synthase 2
chr3_-_55489973 9.249 WNT5A
wingless-type MMTV integration site family, member 5A
chr7_-_41709191 9.240 NM_002192
INHBA
inhibin, beta A
chr21_-_34820916 7.486 NM_203418
RCAN1
regulator of calcineurin 1
chr7_-_27149750 7.362 NM_019102
HOXA5
homeobox A5
chr1_+_168898898 7.280 PRRX1
paired related homeobox 1
chr2_+_66516196 7.098 MEIS1
Meis homeobox 1
chr7_-_27171600 7.020 HOXA9
homeobox A9
chr7_-_27171648 6.376 HOXA9
homeobox A9
chr10_+_24795446 6.030 KIAA1217
KIAA1217
chr7_-_27171673 6.026 NM_152739
HOXA9
homeobox A9
chr14_+_51025604 5.912 NM_001042481
FRMD6
FERM domain containing 6
chr10_+_24795465 5.890 KIAA1217
KIAA1217
chr7_-_83662152 5.814 NM_006080
SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_-_115960807 5.646 NM_001164344
NM_001164345
ZBTB20

zinc finger and BTB domain containing 20

chr9_-_116920232 5.569 NM_002160
TNC
tenascin C
chr2_-_164300758 5.469 NM_018086
FIGN
fidgetin
chr7_-_27108826 5.354 NM_006735
HOXA2
homeobox A2
chr9_+_117955890 5.272 NM_002581
PAPPA
pregnancy-associated plasma protein A, pappalysin 1
chr3_-_115825742 5.102 NM_001164347
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_87989291 4.996 NM_197965
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter family), member 6
chr10_-_33663305 4.985 NRP1
neuropilin 1
chr1_-_20682541 4.923


chr7_+_134226727 4.920 CALD1
caldesmon 1
chr12_-_88270128 4.899 DUSP6
dual specificity phosphatase 6
chr12_+_88268845 4.818 LOC100131490
hypothetical LOC100131490
chr20_+_19903778 4.812 RIN2
Ras and Rab interactor 2
chr16_+_7322751 4.802 NM_145891
NM_145892
NM_145893
RBFOX1


RNA binding protein, fox-1 homolog (C. elegans) 1


chr5_+_174084137 4.415 NM_002449
MSX2
msh homeobox 2
chr12_-_88270369 4.289 DUSP6
dual specificity phosphatase 6
chr11_-_85107569 4.266 NM_206929
SYTL2
synaptotagmin-like 2
chr9_+_108665168 4.250 NM_021224
ZNF462
zinc finger protein 462
chr3_-_150578148 4.250 TM4SF1
transmembrane 4 L six family member 1
chr4_+_160408447 4.233 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr3_-_150578207 4.216 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr12_-_88270375 4.140 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr7_+_134114912 4.125 CALD1
caldesmon 1
chr3_-_150578103 4.083 TM4SF1
transmembrane 4 L six family member 1
chr9_+_674193 4.075


chr6_+_136214495 4.037 NM_018945
PDE7B
phosphodiesterase 7B
chr18_+_30544193 3.982 NM_001198941
NM_032978
DTNA

dystrobrevin, alpha

chr10_-_92671005 3.981 NM_014391
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr5_+_36642424 3.942 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr16_+_85169615 3.896 NM_005250
FOXL1
forkhead box L1
chr3_-_64186151 3.871 NM_198859
PRICKLE2
prickle homolog 2 (Drosophila)
chr6_-_152744022 3.862 SYNE1
spectrin repeat containing, nuclear envelope 1
chr6_-_138862273 3.764


chr6_-_116488458 3.725 NM_002031
FRK
fyn-related kinase
chr9_-_8723893 3.673 NM_001040712
NM_001171025
NM_130391
NM_130392
NM_130393
PTPRD




protein tyrosine phosphatase, receptor type, D




chr11_-_128567302 3.613 NM_001142685
ARHGAP32
Rho GTPase activating protein 32
chr10_+_69539255 3.610 NM_032578
MYPN
myopalladin
chr8_+_77756077 3.576 ZFHX4
zinc finger homeobox 4
chr5_+_59819761 3.575 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr2_-_190635566 3.540 NM_005259
MSTN
myostatin
chr2_+_66516020 3.525 NM_002398
MEIS1
Meis homeobox 1
chr2_+_33213111 3.525 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr8_-_49996353 3.486 NM_003068
SNAI2
snail homolog 2 (Drosophila)
chr3_+_25445071 3.474 RARB
retinoic acid receptor, beta
chr22_-_34566210 3.446 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr7_+_113842284 3.425 NM_001172766
NM_014491
NM_148898
NM_148900
FOXP2



forkhead box P2



chr5_+_36642213 3.413 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr13_-_34948758 3.399 NM_005584
MAB21L1
mab-21-like 1 (C. elegans)
chr13_+_75232797 3.388 NM_015842
LMO7
LIM domain 7
chr12_+_79625538 3.368 NM_002469
MYF6
myogenic factor 6 (herculin)
chr7_+_134226690 3.365 NM_033139
NM_033140
CALD1

caldesmon 1

chr2_-_151052391 3.358 NM_005168
RND3
Rho family GTPase 3
chr3_+_158637273 3.352 NM_002852
PTX3
pentraxin 3, long
chr3_+_174598937 3.347 NM_014932
NLGN1
neuroligin 1
chr13_+_100902942 3.342 NM_004791
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr10_-_29963906 3.291 NM_021738
SVIL
supervillin
chr3_-_21767819 3.269 NM_024697
ZNF385D
zinc finger protein 385D
chr8_+_77756061 3.249 NM_024721
ZFHX4
zinc finger homeobox 4
chr3_-_188946168 3.246 NM_001706
BCL6
B-cell CLL/lymphoma 6
chr14_+_85069217 3.245


chr10_+_52420936 3.243 NM_001098512
PRKG1
protein kinase, cGMP-dependent, type I
chr6_-_138935359 3.241 NM_020464
NHSL1
NHS-like 1
chr3_-_11585264 3.227 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr17_-_44026042 3.215 NM_002147
HOXB5
homeobox B5
chr22_-_34566276 3.208 RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr2_-_189752575 3.190 NM_000393
COL5A2
collagen, type V, alpha 2
chr3_-_71262426 3.170 FOXP1
forkhead box P1
chr5_+_155686333 3.164 NM_000337
NM_001128209
NM_172244
SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr1_+_213245507 3.136 NM_001017424
KCNK2
potassium channel, subfamily K, member 2
chr7_-_5429702 3.104 NM_001080495
TNRC18
trinucleotide repeat containing 18
chr15_+_55298908 3.100 NM_207040
TCF12
transcription factor 12
chr5_-_111119846 3.093 NM_001142483
C5orf13
chromosome 5 open reading frame 13
chr20_-_10602139 3.058 JAG1
jagged 1
chr7_+_134114957 3.054 CALD1
caldesmon 1
chr17_-_44026321 3.049 HOXB5
homeobox B5
chr21_-_35181956 3.049 RUNX1
runt-related transcription factor 1
chr7_+_134114701 3.025 NM_004342
NM_033138
NM_033157
CALD1


caldesmon 1


chr4_-_153493133 3.021 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr3_-_116272911 3.014 NM_001164343
ZBTB20
zinc finger and BTB domain containing 20
chr3_-_150578023 3.014 TM4SF1
transmembrane 4 L six family member 1
chr3_-_55490401 2.988 WNT5A
wingless-type MMTV integration site family, member 5A
chr12_-_88269884 2.930 DUSP6
dual specificity phosphatase 6
chr10_-_21847126 2.911


chr4_-_152366970 2.897 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr2_-_160764819 2.862 NM_000888
ITGB6
integrin, beta 6
chr8_-_13416554 2.857 NM_024767
NM_182643
DLC1

deleted in liver cancer 1

chrX_+_135106578 2.849 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr20_-_14266200 2.845 NM_013281
NM_198391
FLRT3

fibronectin leucine rich transmembrane protein 3

chr5_-_59819642 2.818 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr2_+_66519949 2.785 MEIS1
Meis homeobox 1
chr12_+_40117751 2.780 NM_013377
PDZRN4
PDZ domain containing ring finger 4
chr1_-_27604656 2.771 WASF2
WAS protein family, member 2
chr3_-_55490442 2.764 WNT5A
wingless-type MMTV integration site family, member 5A
chr8_+_70541631 2.756 SULF1
sulfatase 1
chr4_+_183302105 2.740 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr12_-_14024187 2.737 NM_000834
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr22_-_34566367 2.730 NM_001031695
NM_001082576
NM_001082577
NM_014309
RBFOX2



RNA binding protein, fox-1 homolog (C. elegans) 2



chr5_+_127012611 2.704 NM_001048252
CTXN3
cortexin 3
chr7_-_112513379 2.689 NM_001146266
NM_001146267
GPR85

G protein-coupled receptor 85

chr11_+_131285747 2.673 NM_001144058
NM_001144059
NM_016522
NTM


neurotrimin


chr6_+_21701942 2.661 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr4_-_141293572 2.650 MAML3
mastermind-like 3 (Drosophila)
chr5_-_59100194 2.619 NM_001197218
PDE4D
phosphodiesterase 4D, cAMP-specific
chr10_+_111755715 2.595 NM_019903
ADD3
adducin 3 (gamma)
chr7_-_27136876 2.557 NM_002141
HOXA4
homeobox A4
chr13_+_34948977 2.540 NBEA
neurobeachin
chr5_+_66160359 2.538 NM_015183
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_-_59100091 2.532 PDE4D
phosphodiesterase 4D, cAMP-specific
chr20_+_11846536 2.526 NM_014962
BTBD3
BTB (POZ) domain containing 3
chr14_-_91483325 2.508 FBLN5
fibulin 5
chr12_+_118100977 2.497 NM_014365
HSPB8
heat shock 22kDa protein 8
chr4_+_81325447 2.496 NM_020226
PRDM8
PR domain containing 8
chr3_-_71262405 2.477 FOXP1
forkhead box P1
chr8_-_72431274 2.472 NM_172058
NM_172059
NM_172060
EYA1


eyes absent homolog 1 (Drosophila)


chr3_-_64647325 2.458 ADAMTS9
ADAM metallopeptidase with thrombospondin type 1 motif, 9
chr10_+_86174665 2.445 FAM190B
family with sequence similarity 190, member B
chr18_+_30812205 2.440 NM_001143827
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr15_-_31147376 2.440 NM_001103184
FMN1
formin 1
chr1_+_66772393 2.421 NM_032291
SGIP1
SH3-domain GRB2-like (endophilin) interacting protein 1
chr13_-_43908937 2.421 TSC22D1
TSC22 domain family, member 1
chr7_-_27162688 2.415 NM_006896
HOXA7
homeobox A7
chr8_-_93176819 2.404 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr11_-_85108030 2.404 NM_001162952
NM_206930
SYTL2

synaptotagmin-like 2

chr6_-_101018271 2.388 NM_005068
SIM1
single-minded homolog 1 (Drosophila)
chr7_+_113842470 2.376 FOXP2
forkhead box P2
chr18_+_30427279 2.358 NM_001128175
NM_001198938
NM_001198939
NM_001198940
DTNA



dystrobrevin, alpha



chr7_+_113842407 2.334 FOXP2
forkhead box P2
chr10_-_29963847 2.333


chr1_-_85816520 2.330 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr13_+_34948885 2.320 NBEA
neurobeachin
chr6_-_138862271 2.316 NM_001144060
NHSL1
NHS-like 1
chr21_-_38792173 2.314 NM_001136155
NM_182918
ERG

v-ets erythroblastosis virus E26 oncogene homolog (avian)

chr21_+_39117064 2.312 ETS2
v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr8_+_70541412 2.307 NM_001128204
NM_015170
SULF1

sulfatase 1

chr10_-_92670764 2.282 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_159312973 2.280 FAM198B
family with sequence similarity 198, member B
chr20_-_10602429 2.267 NM_000214
JAG1
jagged 1
chr18_-_44723116 2.246 NM_001190823
SMAD7
SMAD family member 7
chr12_-_28016182 2.241 NM_002820
NM_198965
PTHLH

parathyroid hormone-like hormone

chr7_-_27120015 2.203 HOXA3
homeobox A3
chr6_-_56615544 2.185 NM_001723
NM_015548
DST

dystonin

chr7_-_27153892 2.181 NM_024014
HOXA6
homeobox A6
chr6_-_169395972 2.167 NM_003247
THBS2
thrombospondin 2
chr10_+_52421120 2.160 PRKG1
protein kinase, cGMP-dependent, type I
chr2_-_200033445 2.157 SATB2
SATB homeobox 2
chr5_+_92944680 2.152 NM_005654
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr4_-_23500706 2.141 NM_013261
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr6_+_121798443 2.139 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr11_+_34599227 2.139 EHF
ets homologous factor
chr9_+_12764988 2.136 NM_203403
C9orf150
chromosome 9 open reading frame 150
chr14_-_60185659 2.135 NM_005982
SIX1
SIX homeobox 1
chr10_-_116434364 2.130 NM_001003407
NM_001003408
ABLIM1

actin binding LIM protein 1

chr11_+_34599163 2.129 NM_012153
EHF
ets homologous factor
chr10_-_76831142 2.128 ZNF503
zinc finger protein 503
chr1_-_191422346 2.092 NM_003783
B3GALT2
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
chr7_-_96471544 2.091 DLX6-AS1
DLX6 antisense RNA 1 (non-protein coding)
chrX_+_28515479 2.088 NM_014271
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr17_-_36346240 2.079 KRT23
keratin 23 (histone deacetylase inducible)
chr6_+_114285209 2.069 NM_002356
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr12_+_52696908 2.058 NM_014620
NM_153693
HOXC4
HOXC6
homeobox C4
homeobox C6
chr6_+_12825818 2.046 NM_030948
PHACTR1
phosphatase and actin regulator 1
chrX_+_135058402 2.023 NM_001159700
FHL1
four and a half LIM domains 1
chr6_+_144649142 2.017 UTRN
utrophin
chr4_+_169654742 2.010 NM_001166108
NM_016081
PALLD

palladin, cytoskeletal associated protein

chr12_-_90100679 2.010 DCN
decorin
chr5_-_121441910 1.994 NM_002317
LOX
lysyl oxidase
chr2_-_160765008 1.990 ITGB6
integrin, beta 6
chr16_+_81218142 1.985 CDH13
cadherin 13, H-cadherin (heart)
chr1_+_99884018 1.978 NM_017734
PALMD
palmdelphin
chr12_-_90100710 1.968 DCN
decorin
chr1_+_221168388 1.956 NM_032890
DISP1
dispatched homolog 1 (Drosophila)
chr16_-_71650034 1.950 NM_001164766
ZFHX3
zinc finger homeobox 3
chr5_-_1935764 1.949 NM_016358
IRX4
iroquois homeobox 4
chrX_+_135079461 1.938 NM_001167819
FHL1
four and a half LIM domains 1
chr5_-_112658456 1.934 NM_002387
MCC
mutated in colorectal cancers
chr8_-_15140162 1.919 NM_139167
SGCZ
sarcoglycan, zeta
chr3_+_69998064 1.887 NM_198177
MITF
microphthalmia-associated transcription factor
chr15_+_60838053 1.884 TLN2
talin 2
chr4_+_54790190 1.876 PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr11_-_114593838 1.866 CADM1
cell adhesion molecule 1
chr4_+_54790020 1.862 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr2_-_207738858 1.860 NM_003709
KLF7
Kruppel-like factor 7 (ubiquitous)
chr8_-_93176618 1.860 NM_001198629
NM_001198630
NM_001198632
NM_175635
RUNX1T1



runt-related transcription factor 1; translocated to, 1 (cyclin D-related)



chr3_-_188935363 1.839 NM_001134738
BCL6
B-cell CLL/lymphoma 6
chr7_-_13996166 1.831 NM_001163147
NM_004956
ETV1

ets variant 1


Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.30 1.25e-26 GO:0032501 multicellular organismal process
1.42 1.70e-23 GO:0048731 system development
1.37 9.70e-23 GO:0007275 multicellular organismal development
1.34 2.69e-21 GO:0032502 developmental process
1.38 3.35e-21 GO:0048856 anatomical structure development
1.52 9.86e-16 GO:0007399 nervous system development
1.48 2.38e-13 GO:0009653 anatomical structure morphogenesis
1.18 3.07e-11 GO:0050896 response to stimulus
1.58 3.80e-11 GO:0022008 neurogenesis
1.36 1.57e-10 GO:0030154 cell differentiation
1.58 2.22e-10 GO:0048699 generation of neurons
1.34 1.62e-09 GO:0048869 cellular developmental process
1.50 4.77e-09 GO:0009605 response to external stimulus
1.35 7.80e-09 GO:0048513 organ development
1.57 1.92e-08 GO:2000026 regulation of multicellular organismal development
1.88 4.31e-08 GO:0060284 regulation of cell development
1.48 5.07e-08 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.54 9.92e-08 GO:0007155 cell adhesion
1.54 9.92e-08 GO:0022610 biological adhesion
1.58 1.04e-07 GO:0045595 regulation of cell differentiation
1.56 2.42e-07 GO:0030182 neuron differentiation
1.50 2.51e-07 GO:0009888 tissue development
1.48 3.20e-07 GO:0050793 regulation of developmental process
2.29 4.75e-07 GO:0007156 homophilic cell adhesion
1.49 5.68e-07 GO:0040011 locomotion
1.80 8.01e-07 GO:0007411 axon guidance
1.33 1.21e-06 GO:0003008 system process
1.64 1.41e-06 GO:0000904 cell morphogenesis involved in differentiation
1.83 1.44e-06 GO:0016337 cell-cell adhesion
1.46 1.47e-06 GO:0048468 cell development
1.68 3.24e-06 GO:0007409 axonogenesis
1.78 3.75e-06 GO:0001501 skeletal system development
1.52 4.17e-06 GO:0009790 embryo development
1.57 5.24e-06 GO:0048666 neuron development
1.83 6.37e-06 GO:0061061 muscle structure development
1.65 7.58e-06 GO:0048812 neuron projection morphogenesis
1.61 9.13e-06 GO:0031175 neuron projection development
1.65 9.17e-06 GO:0048667 cell morphogenesis involved in neuron differentiation
1.27 1.17e-05 GO:0048523 negative regulation of cellular process
1.54 1.78e-05 GO:0000902 cell morphogenesis
2.53 1.99e-05 GO:0048706 embryonic skeletal system development
1.60 3.11e-05 GO:0072358 cardiovascular system development
1.60 3.11e-05 GO:0072359 circulatory system development
1.19 3.39e-05 GO:0023052 signaling
1.80 4.52e-05 GO:0045596 negative regulation of cell differentiation
1.33 4.66e-05 GO:0050877 neurological system process
1.74 5.64e-05 GO:0022603 regulation of anatomical structure morphogenesis
1.24 7.60e-05 GO:0048519 negative regulation of biological process
1.55 1.02e-04 GO:0006935 chemotaxis
1.55 1.02e-04 GO:0042330 taxis
1.50 1.04e-04 GO:0032989 cellular component morphogenesis
1.55 1.25e-04 GO:0032990 cell part morphogenesis
1.55 1.28e-04 GO:0048858 cell projection morphogenesis
1.39 1.48e-04 GO:0042127 regulation of cell proliferation
2.04 1.53e-04 GO:0045165 cell fate commitment
1.48 1.67e-04 GO:0030030 cell projection organization
1.68 2.13e-04 GO:0051093 negative regulation of developmental process
1.33 2.24e-04 GO:0051239 regulation of multicellular organismal process
1.63 2.34e-04 GO:0009792 embryo development ending in birth or egg hatching
1.64 2.36e-04 GO:0043009 chordate embryonic development
1.58 2.54e-04 GO:0032583 regulation of gene-specific transcription
1.44 2.62e-04 GO:0010557 positive regulation of macromolecule biosynthetic process
1.57 3.27e-04 GO:0051094 positive regulation of developmental process
2.00 3.52e-04 GO:0043062 extracellular structure organization
1.11 4.25e-04 GO:0050794 regulation of cellular process
1.51 4.58e-04 GO:0045892 negative regulation of transcription, DNA-dependent
1.11 5.21e-04 GO:0050789 regulation of biological process
1.50 5.57e-04 GO:0051253 negative regulation of RNA metabolic process
1.76 5.66e-04 GO:0050767 regulation of neurogenesis
1.86 5.77e-04 GO:0007517 muscle organ development
2.04 6.12e-04 GO:0060537 muscle tissue development
2.55 6.95e-04 GO:0007519 skeletal muscle tissue development
1.48 6.99e-04 GO:0009887 organ morphogenesis
1.23 7.42e-04 GO:0042221 response to chemical stimulus
1.10 7.49e-04 GO:0065007 biological regulation
1.18 7.96e-04 GO:0007165 signal transduction
1.44 9.76e-04 GO:0010628 positive regulation of gene expression
2.47 1.02e-03 GO:0060538 skeletal muscle organ development
1.46 1.09e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.58 1.29e-03 GO:0000122 negative regulation of transcription from RNA polymerase II promoter
1.69 1.56e-03 GO:0051960 regulation of nervous system development
2.05 1.56e-03 GO:0014706 striated muscle tissue development
1.78 1.61e-03 GO:0048514 blood vessel morphogenesis
1.67 1.86e-03 GO:0001944 vasculature development
1.80 2.19e-03 GO:0045664 regulation of neuron differentiation
1.69 2.24e-03 GO:0001568 blood vessel development
1.43 2.34e-03 GO:0007167 enzyme linked receptor protein signaling pathway
1.34 2.38e-03 GO:0007154 cell communication
1.51 2.56e-03 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
1.49 2.59e-03 GO:0007417 central nervous system development
1.88 2.89e-03 GO:0001525 angiogenesis
2.34 3.11e-03 GO:0022612 gland morphogenesis
1.58 3.31e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
1.44 3.46e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 6.11e-03 GO:0009891 positive regulation of biosynthetic process
1.36 6.43e-03 GO:0031328 positive regulation of cellular biosynthetic process
1.42 7.31e-03 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.45 7.47e-03 GO:0048634 regulation of muscle organ development
2.45 7.47e-03 GO:0048704 embryonic skeletal system morphogenesis
1.42 7.64e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
2.94 8.17e-03 GO:0051153 regulation of striated muscle cell differentiation
1.14 8.39e-03 GO:0051716 cellular response to stimulus
1.62 8.66e-03 GO:0031667 response to nutrient levels
1.76 8.72e-03 GO:0007584 response to nutrient
1.56 1.12e-02 GO:0007389 pattern specification process
1.48 1.13e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.42 1.14e-02 GO:0010629 negative regulation of gene expression
1.68 1.15e-02 GO:0003002 regionalization
2.44 1.23e-02 GO:0016202 regulation of striated muscle tissue development
1.87 1.36e-02 GO:0034330 cell junction organization
1.50 1.43e-02 GO:0016477 cell migration
1.39 1.48e-02 GO:0051254 positive regulation of RNA metabolic process
1.39 1.49e-02 GO:0031327 negative regulation of cellular biosynthetic process
1.40 1.78e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.74 1.88e-02 GO:0048732 gland development
1.57 2.04e-02 GO:0009991 response to extracellular stimulus
3.35 2.34e-02 GO:0002053 positive regulation of mesenchymal cell proliferation
2.87 2.43e-02 GO:0048641 regulation of skeletal muscle tissue development
1.47 2.56e-02 GO:0048870 cell motility
1.47 2.56e-02 GO:0051674 localization of cell
1.84 2.58e-02 GO:0001655 urogenital system development
1.89 2.62e-02 GO:0048705 skeletal system morphogenesis
1.34 2.70e-02 GO:0007600 sensory perception
1.43 2.80e-02 GO:0008284 positive regulation of cell proliferation
2.27 3.16e-02 GO:0051147 regulation of muscle cell differentiation
1.42 3.22e-02 GO:0006928 cellular component movement
1.88 3.33e-02 GO:0042692 muscle cell differentiation
2.43 3.34e-02 GO:0050808 synapse organization
1.37 3.48e-02 GO:0009890 negative regulation of biosynthetic process
1.35 3.60e-02 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.01 3.62e-02 GO:0060688 regulation of morphogenesis of a branching structure
1.54 3.99e-02 GO:0045597 positive regulation of cell differentiation
1.32 4.25e-02 GO:0031324 negative regulation of cellular metabolic process
1.32 4.55e-02 GO:0010605 negative regulation of macromolecule metabolic process
1.34 4.67e-02 GO:0051173 positive regulation of nitrogen compound metabolic process
1.35 4.74e-02 GO:0007267 cell-cell signaling
1.37 4.87e-02 GO:0009719 response to endogenous stimulus
1.67 4.88e-02 GO:0043193 positive regulation of gene-specific transcription
3.20 4.93e-02 GO:0007435 salivary gland morphogenesis

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 3.21e-09 GO:0005886 plasma membrane
1.20 4.94e-09 GO:0071944 cell periphery
1.44 1.83e-08 GO:0044421 extracellular region part
1.83 3.12e-08 GO:0005578 proteinaceous extracellular matrix
1.73 9.87e-08 GO:0031012 extracellular matrix
1.29 1.29e-07 GO:0005576 extracellular region
1.47 6.48e-05 GO:0030054 cell junction
2.09 1.20e-04 GO:0030016 myofibril
1.39 1.59e-04 GO:0005615 extracellular space
1.22 1.79e-04 GO:0044459 plasma membrane part
2.01 3.24e-04 GO:0043292 contractile fiber
1.50 2.48e-03 GO:0045202 synapse
1.96 2.91e-03 GO:0044420 extracellular matrix part
1.96 2.91e-03 GO:0044449 contractile fiber part
1.47 1.34e-02 GO:0009986 cell surface
2.63 1.64e-02 GO:0005581 collagen
2.33 1.68e-02 GO:0031983 vesicle lumen
1.69 2.43e-02 GO:0070161 anchoring junction
4.60 3.55e-02 GO:0005614 interstitial matrix
2.30 4.51e-02 GO:0034774 secretory granule lumen
1.88 4.52e-02 GO:0030017 sarcomere

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.57 1.47e-08 GO:0043565 sequence-specific DNA binding
1.42 9.27e-07 GO:0001071 nucleic acid binding transcription factor activity
1.42 9.27e-07 GO:0003700 sequence-specific DNA binding transcription factor activity
1.51 1.80e-06 GO:0005509 calcium ion binding
1.39 6.33e-06 GO:0030528 transcription regulator activity
1.38 2.02e-05 GO:0005102 receptor binding
1.80 2.56e-04 GO:0000975 regulatory region DNA binding
1.80 2.56e-04 GO:0001067 regulatory region nucleic acid binding
1.80 2.56e-04 GO:0044212 transcription regulatory region DNA binding
1.79 5.47e-04 GO:0010843 promoter binding
1.55 5.02e-03 GO:0003779 actin binding
1.09 6.85e-03 GO:0005515 protein binding
1.75 1.34e-02 GO:0008083 growth factor activity
2.34 1.79e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.37 2.00e-02 GO:0003707 steroid hormone receptor activity
1.74 3.41e-02 GO:0005539 glycosaminoglycan binding
1.71 3.52e-02 GO:0001871 pattern binding
1.71 3.52e-02 GO:0030247 polysaccharide binding
1.18 4.81e-02 GO:0004871 signal transducer activity
1.18 4.81e-02 GO:0060089 molecular transducer activity